Reactome | PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1

PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1

Stable Identifier

R-HSA-9646347

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PolyUb-misfolded proteins bind VCP:HDAC6:HSP90:HSF1

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When the proteasome machinery is deregulated, misfolded proteins are eliminated by forming aggresomes. To this end, poly-ubiquitinated misfolded proteins bind to a complex comprising of Transitional endoplasmic reticulum ATPase (VCP), Histone deacetylase 6 (HDAC6), Heat shock protein HSP 90 (HSP90) and Heat shock factor protein 1 (HSF1). HDAC6 in the complex interacts with the ubiquitin molecules in the misfolded proteins. Following this binding event, this complex starts dissociating (Boyault C et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17785525	HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates Garrido, C, Gilquin, B, Zhang, Y, Khochbin, S, Vourc'h, C, Matthias, P, Yao, TP, Fritah, S, Kwon, SH, Caron, C, Boyault, C	Genes Dev.	2007