Diseases of programmed cell death

Stable Identifier
Homo sapiens
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Programmed cell death is frequently impaired in cancer and is thought to significantly contribute to resistance to chemotherapy. Mutations and perturbations in expression of different proteins involved in programmed cell death, such as TP53 (p53), BH3-only family proteins, caspases and their regulators enable malignant cells to evade apoptosis (Ghavami et al. 2009, Chao et al. 2011, Wong 2011, Fernald and Kurokawa 2013, Ichim and Tait 2016).
Literature References
PubMed ID Title Journal Year
19505876 Apoptosis and cancer: mutations within caspase genes

Hashemi, M, Halayko, AJ, Ghavami, S, Ande, SR, Yeganeh, B, Los, M, Kadkhoda, K, Wiechec, E, Eshraghi, M, Bus, CJ, Xiao, W

J. Med. Genet. 2009
21943236 Apoptosis in cancer: from pathogenesis to treatment

Wong, RS

J. Exp. Clin. Cancer Res. 2011
22158022 Programmed cell removal: a new obstacle in the road to developing cancer

Weissman, IL, Chao, MP, Majeti, R

Nat. Rev. Cancer 2011
23958396 Evading apoptosis in cancer

Fernald, K, Kurokawa, M

Trends Cell Biol. 2013
27364482 A fate worse than death: apoptosis as an oncogenic process

Ichim, G, Tait, SW

Nat. Rev. Cancer 2016
as an event of
Name Identifier Synonyms
neurodegenerative disease DOID:1289 degenerative disease, Neurodegenerative disease
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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