Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function

Stable Identifier
R-HSA-9645722
Type
Pathway
Species
Homo sapiens
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Cancer-derived missense mutations in the CDKN2A gene that affect the C-terminal arginine-rich region of p14ARF (also known as CDKN2A transcription isoform 4, CDKN2A-4, p14 or ARF) impair p14ARF binding to the mitochondrial matrix protein C1QBP and interfere with p53-mediated apoptosis. Many mutations in the CDKN2A locus that affect C-terminal arginines of p14ARF are silent in p16INK4A (CDKN2A-1) (Itahana and Zhang 2008).

Literature References
PubMed ID Title Journal Year
18538737 Mitochondrial p32 is a critical mediator of ARF-induced apoptosis

Itahana, K, Zhang, Y

Cancer Cell 2008
Participants
Participates
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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BioModels Database
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