p-STAT5 dissociates from activator:STAT5 complex

Stable Identifier
R-HSA-9645134
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Signal transducer and activator of transcription (STAT5A/STAT5B) is activated by a range of upstream signals including cytokines and growth factors. Activators bind and phosphorylate STAT5 following which STAT5 is released from the complex and translocates to the nucleus to regulate gene transcription (Nabinger et al, 2013).

Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
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