Activators bind STAT5

Stable Identifier
R-HSA-9645126
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activators bind STAT5
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Signal transducer and activator of transcription (STAT5A/STAT5B) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. STAT5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds STAT5 to initiate its phosphorylation (Nabinger et al, 2013).
Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Boswell, HS, Ramdas, B, Feng, GS, Zeng, L, Kapur, R, He, Y, Liu, Z, Zhang, X, Sandusky, GE, Zhang, ZY, Fukuda, S, Li, XJ, Nabinger, SC, Yu, M, Richine, B, Chan, RJ, Goenka, S, Bowling, JD

Leukemia 2013
Participants
Input
Output
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as an event of
Inferred From
Activators bind Stat5 (Mus musculus)
Authored
Varusai, TM  (2019-02-23)
Reviewed
Traer, E  (2019-05-03)
Joshi, S  (2019-05-21)
Created
Varusai, TM  (2019-05-04)
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