Activators bind STAT5

Stable Identifier
R-HSA-9645126
Type
Reaction [binding]
Species
Homo sapiens
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Signal transducer and activator of transcription (STAT5A/STAT5B) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. STAT5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds STAT5 to initiate its phosphorylation (Nabinger et al, 2013).

Literature References
PubMed ID Title Journal Year
23103841 The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

Nabinger, SC, Li, XJ, Ramdas, B, He, Y, Zhang, X, Zeng, L, Richine, B, Bowling, JD, Fukuda, S, Goenka, S, Liu, Z, Feng, GS, Yu, M, Sandusky, GE, Boswell, HS, Zhang, ZY, Kapur, R, Chan, RJ

Leukemia 2013
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