NPAS4:ARNT2 binds BDNF gene promoter

Stable Identifier
R-HSA-9644879
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4:ARNT2 binds BDNF gene promoter
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Based on in vitro studies, human NPAS4 in complex with human ARTN2 binds to promoters I and IV of the BDNF gene (Pruunsild et al. 2011). In mouse neurons, it was shown that endogenous Npas4 binds promoters I and IV of the endogenous mouse Bdnf gene (Lin et al. 2008, Bloodgood et al. 2013), as well as intron III (Bloodgood et al. 2013). The NPAS4:ARNT2 complex is shown as a set member, while NPAS4:ARNT and NPAS4:ARNTL are shown as set candidates in the context of binding to the BDNF gene promoter.
Literature References
PubMed ID Title Journal Year
21368041 Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene

Orav, E, Timmusk, T, Koppel, I, Pruunsild, P, Sepp, M

J. Neurosci. 2011
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Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-04-26)
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