Parkin transfers Ub to misfolded proteins

Stable Identifier
R-HSA-9641111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Parkin transfers Ub to misfolded proteins
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Misfolded proteins in the cytosol are tagged with ubiquitin molecules via the E2 UBE2N/UBE2V1 conjugation complex and E3 ligase Parkin. Misfolded proteins bind Parkin and subsequently Parkin transfers ubiquitin from E2 complex to the proteins (Olzmann JA et al. 2007).
Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L

J. Cell Biol. 2007
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Orthologous Events
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Parkin transfers Ub to misfolded proteins (Drosophila melanogaster)
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Parkin transfers Ub to misfolded proteins (Plasmodium falciparum)
Parkin transfers Ub to misfolded proteins (Rattus norvegicus)
Parkin transfers Ub to misfolded proteins (Saccharomyces cerevisiae)
Parkin transfers Ub to misfolded proteins (Schizosaccharomyces pombe)
Parkin transfers Ub to misfolded proteins (Sus scrofa)
Authored
Varusai, TM  (2019-04-04)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-04-04)
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