PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1

Stable Identifier
R-HSA-9641109
Type
Reaction [dissociation]
Species
Homo sapiens
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Misfolded proteins from cellular stress are destined for degradation via ubiquitination. The E2 ubiquitin conjugating enzymes UBE2N/UBE2V1 and E3 ligase enzyme Parkin recruit and tag multiple K63-linked ubiquitin molecules to the misfolded proteins. Subsequently, the polyubiquitinated proteins dissociate from the E2/E3 system and are driven to degradation (Olzmann JA et al. 2007).

Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Olzmann, JA, Li, L, Chudaev, MV, Chen, J, Perez, FA, Palmiter, RD, Chin, LS

J. Cell Biol. 2007
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