PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1

Stable Identifier
R-HSA-9641109
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1
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Misfolded proteins from cellular stress are destined for degradation via ubiquitination. The E2 ubiquitin conjugating enzymes UBE2N/UBE2V1 and E3 ligase enzyme Parkin recruit and tag multiple K63-linked ubiquitin molecules to the misfolded proteins. Subsequently, the polyubiquitinated proteins dissociate from the E2/E3 system and are driven to degradation (Olzmann JA et al. 2007).
Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L

J. Cell Biol. 2007
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Orthologous Events
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PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Drosophila melanogaster)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Mus musculus)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Plasmodium falciparum)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Schizosaccharomyces pombe)
Authored
Varusai, TM  (2019-04-04)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-04-04)
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