Parkin binds Ub:UBE2N:UBE2V1

Stable Identifier
R-HSA-9641089
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Parkin binds Ub:UBE2N:UBE2V1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. Consequently, the E3 ligase PRKN (Parkin) binds this complex and facilitates the addition of more ubiquitin molecules. (Olzmann JA et al. 2007).
Literature References
PubMed ID Title Journal Year
17846173 Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L

J. Cell Biol. 2007
Participants
Input
Output
Participates
as an event of
Orthologous Events
Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)
Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)
Parkin binds Ub:UBE2N:UBE2V1 (Dictyostelium discoideum)
Parkin binds Ub:UBE2N:UBE2V1 (Drosophila melanogaster)
Parkin binds Ub:UBE2N:UBE2V1 (Mus musculus)
Parkin binds Ub:UBE2N:UBE2V1 (Plasmodium falciparum)
Parkin binds Ub:UBE2N:UBE2V1 (Saccharomyces cerevisiae)
Parkin binds Ub:UBE2N:UBE2V1 (Schizosaccharomyces pombe)
Authored
Varusai, TM  (2019-04-02)
Reviewed
Metzakopian, E  (2019-05-24)
Created
Varusai, TM  (2019-04-04)
Cite Us!