Ubiquitination is the covalent attachment of ubiquitin molecules to substrate proteins with three enzymatic steps - E1 ubiquitin activation, E2 ubiquitin conjugation and E3 ubiquitin protein ligase. UBE2V1 and UBE2N are E2 ubiquitin-conjugating enzymes that form a complex and bind ubiquitin molecules at K63. Consequently, the E3 ligase PRKN (Parkin) binds this complex and facilitates the addition of more ubiquitin molecules. (Olzmann JA et al. 2007).
Chin, LS, Palmiter, RD, Chudaev, MV, Perez, FA, Olzmann, JA, Chen, J, Li, L
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