Nucleocapsids most likely reach the cytoplasm by obtaining a temporary envelope at the inner nuclear membrane passage through the perinuclear space and de-envelopment at the outer nuclear membrane. Once delivered to the cytoplasm, further assembly occurs within the cytoplasmic viral assembly compartment (AC) composed of cellular membranes and organelles that support the final steps in maturation and release. Subsequently transport is directed to sites where tegumented nucleocapsids obtain a second, final envelope to become virions.
Knipe, DM, Howley, PM
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