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Addition of Tegument to HCMV Nucleocapsid C
Stable Identifier
R-HSA-9640368
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
host cell viral assembly compartment
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
Addition of Tegument to HCMV Nucleocapsid C (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nucleocapsids most likely reach the cytoplasm by obtaining a temporary envelope at the inner nuclear membrane passage through the perinuclear space and de-envelopment at the outer nuclear membrane. Once delivered to the cytoplasm, further assembly occurs within the cytoplasmic viral assembly compartment (AC) composed of cellular membranes and organelles that support the final steps in maturation and release. Subsequently transport is directed to sites where tegumented nucleocapsids obtain a second, final envelope to become virions.
Literature References
PubMed ID
Title
Journal
Year
Fields Virology
Knipe, DM
,
Howley, PM
2013
Participants
Input
HCMV C Nucleocapsid:NEC2 [host cell viral assembly compartment]
(Human cytomegalovirus)
x 220
IRS1 [cytosol]
(Human cytomegalovirus)
x 750
RIR1 [cytosol]
(Human cytomegalovirus)
x 220
TRS1 [cytosol]
(Human cytomegalovirus)
UL103 [cytosol]
(Human cytomegalovirus)
UL112/UL113 [cytosol]
(Human cytomegalovirus)
UL23 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL24 [host cell viral assembly compartment]
(Human cytomegalovirus)
x 350
UL25 [cytosol]
(Human cytomegalovirus)
x 15
UL26 [cytosol]
(Human cytomegalovirus)
x 80
UL35 [cytosol]
(Human cytomegalovirus)
UL36 [cytosol]
(Human cytomegalovirus)
UL38 [cytosol]
(Human cytomegalovirus)
UL43 [cytosol]
(Human cytomegalovirus)
UL44 [cytosol]
(Human cytomegalovirus)
x 240
UL47:UL48 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL54 [cytosol]
(Human cytomegalovirus)
UL69 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL71 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL76 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL79 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL82 [cytosol]
(Human cytomegalovirus)
UL83 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL84 [cytosol]
(Human cytomegalovirus)
x 100
UL88 [host cell viral assembly compartment]
(Human cytomegalovirus)
x 200
UL94 [host cell viral assembly compartment]
(Human cytomegalovirus)
UL96 [cytosol]
(Human cytomegalovirus)
UL97 [cytosol]
(Human cytomegalovirus)
UL99 [host cell viral assembly compartment]
(Human cytomegalovirus)
US22 [cytosol]
(Human cytomegalovirus)
US23 [cytosol]
(Human cytomegalovirus)
Output
HCMV Tegumented Virion [viral tegument]
(Human cytomegalovirus)
NEC2 [cytosol]
(Human cytomegalovirus)
Participates
as an event of
HCMV Late Events (Homo sapiens)
Event Information
Go Biological Process
viral life cycle (0019058)
Disease
Name
Identifier
Synonyms
viral infectious disease
DOID:934
Viral disease, virus infection, virus infection
Authored
Gillespie, ME (2019-03-09)
Reviewed
Streblow, DN (2019-10-18)
Caposio, P (2019-10-18)
Created
Gillespie, ME (2019-03-25)
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