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DeHA hydrolyses to threonate and oxalate
Stable Identifier
R-HSA-9640316
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin C (ascorbate) metabolism (Homo sapiens)
DeHA hydrolyses to threonate and oxalate (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ascorbate can autoxidise, generating superoxide and its dismutation product H2O2. The resulting dehydroascorbate (DeHA) gets oxidised by H2O2 and hydrolyses to threonate and oxalate (Simpson & Ortwerth 2000).
Literature References
PubMed ID
Title
Journal
Year
10727845
The non-oxidative degradation of ascorbic acid at physiological conditions
Ortwerth, BJ
,
Simpson, GL
Biochim. Biophys. Acta
2000
Participants
Input
DeHA [cytosol]
H2O [cytosol]
H2O2 [cytosol]
Output
oxalate [cytosol]
threonate [cytosol]
Participates
as an event of
Vitamin C (ascorbate) metabolism (Homo sapiens)
Authored
Stephan, R (2019-03-25)
Reviewed
D'Eustachio, P (2019-04-03)
Created
Jassal, B (2019-03-25)
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