Reactome | BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1

BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1

Stable Identifier

R-HSA-9640254

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1

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BMT2 (SAMTOR) binds GATOR1 and acts upstream of GATOR1 and KICSTOR to inhibit mTORC1 activation (Gu et al. 2017). Upon binding S-adenosymethionine, a metabolic derivative of the amino acid methionine, SAMTOR dissociates from GATOR1 and mTORC1 activity is increased through an uncharacterized mechanism (Gu et al. 2017). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
29123071	SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway Sabatini, DM, Scaria, SM, Gu, X, Saxton, RA, Gygi, SP, Liu, GY, Harper, JW, Condon, KJ, Krawczyk, PA, Orozco, JM	Science	2017
28199306	KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 Sabatini, DM, Petri, S, Condon, KJ, Shen, K, Orozco, JM, Scaria, SM, Gu, X, Frankel, WN, Chantranupong, L, Kedir, J, Abu-Remaileh, M, Wyant, GA, Wolfson, RL	Nature	2017