BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1

Stable Identifier
R-HSA-9640254
Type
Reaction [uncertain]
Species
Homo sapiens
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BMT2 (SAMTOR) binds GATOR1 and acts upstream of GATOR1 and KICSTOR to inhibit mTORC1 activation (Gu et al. 2017). Upon binding S-adenosymethionine, a metabolic derivative of the amino acid methionine, SAMTOR dissociates from GATOR1 and mTORC1 activity is increased through an uncharacterized mechanism (Gu et al. 2017). GATOR1 is recruited to the lysosomal membrane by the KICSTOR complex (Wolfson et al. 2017).

Literature References
PubMed ID Title Journal Year
28199306 KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Wolfson, RL, Chantranupong, L, Wyant, GA, Gu, X, Orozco, JM, Shen, K, Condon, KJ, Petri, S, Kedir, J, Scaria, SM, Abu-Remaileh, M, Frankel, WN, Sabatini, DM

Nature 2017
29123071 SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

Gu, X, Orozco, JM, Saxton, RA, Condon, KJ, Liu, GY, Krawczyk, PA, Scaria, SM, Harper, JW, Gygi, SP, Sabatini, DM

Science 2017
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