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CASTOR1 [cytosol]
Stable Identifier
R-HSA-9640228
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GATSL3, fullName evidence="10"Cytosolic arginine sensor for mTORC1 subunit 1, CAST1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
CASTOR1:L-Arg dimer [cytosol] (Homo sapiens)
CASTOR1:L-Arg [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
CASTOR1 dimer [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
CASTOR1:L-Arg:CASTOR2 [cytosol] (Homo sapiens)
CASTOR1:L-Arg [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
CASTOR1:CASTOR2 [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
CASTOR1 dimer [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
CASTOR1:CASTOR2 [cytosol] (Homo sapiens)
CASTOR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WTX7 GATSL3
Gene Names
GATSL3, CASTOR1
Chain
chain:1-329
Reference Genes
BioGPS Gene:652968 GATSL3
COSMIC (genes):CASTOR1 GATSL3
CTD Gene:652968 GATSL3
dbSNP Gene:652968 GATSL3
ENSEMBL:ENSG00000239282 GATSL3
HGNC:34423 GATSL3
KEGG:hsa:652968 GATSL3
Monarch:652968 GATSL3
NCBI Gene:652968 GATSL3
OMIM:617034 GATSL3
UCSC:Q8WTX7 GATSL3
Reference Transcript
RefSeq:NM_001037666.3 GATSL3
Other Identifiers
11719524_a_at
16933774
226613_3p_at
226613_PM_at
226613_at
233528_PM_s_at
233528_s_at
3957206
3957208
3957209
3957210
3957211
3957212
3957213
3957214
3957215
3957216
3957217
3957218
3957219
3957220
3957221
3957222
3957223
52049_at
652968
8075322
A_33_P3226050
A_33_P3227716
GE86919
GO:0005515
GO:0005737
GO:0005829
GO:0034198
GO:0034618
GO:0042802
GO:0061700
GO:0140299
GO:0140311
GO:0140313
GO:1903577
GO:1904262
GO:1904263
HMNXSV003047003
Hs.4232.0.S1_3p_at
Hs.4232.0.S1_3p_x_at
Hs.4232.1.S1_3p_a_at
ILMN_2098418
Participates
as a component of
CASTOR1:CASTOR2 [cytosol] (Homo sapiens)
CASTOR1:L-Arg [cytosol] (Homo sapiens)
CASTOR1 dimer [cytosol] (Homo sapiens)
Inferred To
Castor1 [cytosol]
(Mus musculus)
Castor1 [cytosol]
(Rattus norvegicus)
Ghost homologue of CASTOR1 [cytosol]
(Dictyostelium discoideum)
CASTOR1 [cytosol]
(Bos taurus)
CASTOR1 [cytosol]
(Canis familiaris)
CASTOR1 [cytosol]
(Gallus gallus)
CASTOR1 [cytosol]
(Sus scrofa)
castor1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001032755.1
ENSEMBL
ENSG00000239282
,
ENST00000407689
,
ENSP00000384183
OpenTargets
ENSG00000239282
GeneCards
CASTOR1
HPA
ENSG00000239282-CASTOR1
PRO
Q8WTX7
Pharos - Targets
Q8WTX7
PDB
5GT7
,
5I2C
,
5GS9
,
5GT8
,
5GV2
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.556
3
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