RRAGA,B exchanges GDP for GTP

Stable Identifier
R-HSA-9640167
Type
Reaction
Species
Homo sapiens
Compartment
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Upon binding L-arginine, SLC38A9 acts as a guanyl nucleotide exchange factor (GEF) that enhances the conversion of RRAGA:GDP (RagA:GDP, and by inference RRAGB:GDP, RagB:GDP) to RRAGA:GTP, the active form (Shen and Sabatini 2018). The Ragulator complex also shows GEF activity for RRAGA,B (Bar-Peled et al. 2012). SH3BP4 inhibits loading of GTP onto RRAGB during amino acid starvation (Kim et al. 2012). The binding of GTP by RRAGA,B appears to inhibit binding of GTP by RRAGC,D (Shen et al. 2017).

Literature References
PubMed ID Title Journal Year
22575674 SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling

Kim, YM, Stone, M, Hwang, TH, Kim, YG, Dunlevy, JR, Griffin, TJ, Kim, DH

Mol. Cell 2012
30181260 Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

Shen, K, Sabatini, DM

Proc. Natl. Acad. Sci. U.S.A. 2018
22980980 Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Bar-Peled, L, Schweitzer, LD, Zoncu, R, Sabatini, DM

Cell 2012
29056322 Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Shen, K, Choe, A, Sabatini, DM

Mol. Cell 2017
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created