Reactome | RRAGA,B exchanges GDP for GTP

RRAGA,B exchanges GDP for GTP

Stable Identifier

R-HSA-9640167

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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Upon binding L-arginine, SLC38A9 acts as a guanyl nucleotide exchange factor (GEF) that enhances the conversion of RRAGA:GDP (RagA:GDP, and by inference RRAGB:GDP, RagB:GDP) to RRAGA:GTP, the active form (Shen and Sabatini 2018). The Ragulator complex also shows GEF activity for RRAGA,B (Bar-Peled et al. 2012). SH3BP4 inhibits loading of GTP onto RRAGB during amino acid starvation (Kim et al. 2012). The binding of GTP by RRAGA,B appears to inhibit binding of GTP by RRAGC,D (Shen et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
30181260	Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms Sabatini, DM, Shen, K	Proc. Natl. Acad. Sci. U.S.A.	2018
22575674	SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling Stone, M, Dunlevy, JR, Kim, YM, Kim, DH, Griffin, TJ, Kim, YG, Hwang, TH	Mol. Cell	2012
22980980	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 Sabatini, DM, Zoncu, R, Bar-Peled, L, Schweitzer, LD	Cell	2012
29056322	Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability Sabatini, DM, Choe, A, Shen, K	Mol. Cell	2017