Misfolded proteins translocate from cilium to cytosol

Stable Identifier
R-HSA-9640114
Type
Reaction [transition]
Species
Homo sapiens
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Cellular stress factors damage several cilia proteins and result in their misfolding. These misfolded proteins are translocated into the cytosol of the cell where they are ubiquitinated and eliminated (Lam HC et al. 2013). Confirmatory experiments were performed in mice.

Literature References
PubMed ID Title Journal Year
24200693 Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction

Lam, HC, Cloonan, SM, Bhashyam, AR, Haspel, JA, Singh, A, Sathirapongsasuti, JF, Cervo, M, Yao, H, Chung, AL, Mizumura, K, An, CH, Shan, B, Franks, JM, Haley, KJ, Owen, CA, Tesfaigzi, Y, Washko, GR, Quackenbush, J, Silverman, EK, Rahman, I, Kim, HP, Mahmood, A, Biswal, SS, Ryter, SW, Choi, AM

J. Clin. Invest. 2013
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