KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane]

Stable Identifier
R-HSA-9639275
Type
Complex
Species
Homo sapiens
Compartment
lysosomal membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25819761 Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Lee, JH, Semple, IA, Ro, SH, Cho, US, Guan, KL, Park, H, Park, HW, Kim, M, Wang, W, Karin, M, Kim, JS

Sci Rep 2015
26449471 Sestrin2 is a leucine sensor for the mTORC1 pathway

Sabatini, DM, Scaria, SM, Saxton, RA, Chantranupong, L, Cantor, JR, Shen, K, Wolfson, RL

Science 2016
Participants
components
Participates
as an input of
This entity regulates
Positively
Inferred To
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Bos taurus)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Canis familiaris)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Dictyostelium discoideum)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Gallus gallus)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Mus musculus)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Rattus norvegicus)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Sus scrofa)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Xenopus tropicalis)
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