Reactome | PGM1:Mg2+ isomerises G6P to G1P

PGM1:Mg2+ isomerises G6P to G1P

Stable Identifier

R-HSA-9638127

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

alpha-D-Glucose 6-phosphate <=> D-Glucose 1-phosphate

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Cytosolic phosphoglucomutase1 (PGM1) catalyses the reversible conversion of glucose 6-phosphate (G6P) to glucose 1-phosphate (G1P) (Drago et al. 1991). Two PGM isoenzymes, both monomers, have been identified which both require Mg2+ as cofactor. PGM1 is the major form found in most tissues except erythrocytes, where PGM2 is abundant (March et al. 1993; Parrington et al. 1968; Putt et al. 1993). PGM2 also has substantial phosphopentomutase activity (Maliekal et al. 2007) and its primary physiological in normal tissues in vivo is not clear. Cytosolic glucose 1,6-bisphosphate synthase (PGM2L1) also possesses phosphoglucomutase activity (Maliekal et al. 2007, Veiga-da-Cunha et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18927083	Mammalian phosphomannomutase PMM1 is the brain IMP-sensitive glucose-1,6-bisphosphatase Veiga-da-Cunha, M, Vleugels, W, Maliekal, P, Matthijs, G, Van Schaftingen, E	J. Biol. Chem.	2008
7902568	The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination March, RE, Putt, W, Hollyoake, M, Ives, JH, Lovegrove, JU, Hopkinson, DA, Edwards, YH, Whitehouse, DB	Proc Natl Acad Sci U S A	1993
17804405	Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family Maliekal, P, Sokolova, T, Vertommen, D, Veiga-da-Cunha, M, Van Schaftingen, E	J Biol Chem	2007
1840235	Antigenic analysis of the major human phosphoglucomutase isozymes: PGM1, PGM2, PGM3 and PGM4 Drago, GA, Hopkinson, DA, Westwood, SA, Whitehouse, DB	Ann Hum Genet	1991
8257433	Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon Putt, W, Ives, JH, Hollyoake, M, Hopkinson, DA, Whitehouse, DB, Edwards, YH	Biochem J	1993