ACY3:Zn2+ dimer hydrolyses mercapturic acids

Stable Identifier
R-HSA-9638046
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine
ReviewStatus
5/5
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ACY3:Zn2+ dimer hydrolyses mercapturic acids
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Cytosolic aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acylated amino acids and N-acylcysteine-S-conjugates (Lindner et al. 2003). They are functional as dimers and utilise zinc as a cofactor.
Literature References
PubMed ID Title Journal Year
12933810 Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family

Lindner, HA, Cygler, M, Ménard, R, Hecker, R, Alary, A, Lunin, VV

J. Biol. Chem. 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

aminoacylase activity of ACY3:Zn2+ dimer [cytosol]

Physical Entity
ACY3:Zn2+ dimer [cytosol] (Homo sapiens)
Activity
aminoacylase activity (GO:0004046)
Orthologous Events
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2014-05-12)
Reviewed
D'Eustachio, P  (2014-05-22)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2019-02-25)
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