ACY3:Zn2+ dimer hydrolyses mercapturic acids

Stable Identifier
R-HSA-9638046
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
an N-acetyl-L-cysteine-S-conjugate + H2O => acetate + an S-substituted L-cysteine
ReviewStatus
5/5
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ACY3:Zn2+ dimer hydrolyses mercapturic acids
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Cytosolic aminocyclases 1 and 3 (ACY1,3) can hydrolyse N-acylated amino acids and N-acylcysteine-S-conjugates (Lindner et al. 2003). They are functional as dimers and utilise zinc as a cofactor.
Literature References
PubMed ID Title Journal Year
12933810 Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family

Lindner, HA, Lunin, VV, Alary, A, Hecker, R, Cygler, M, Ménard, R

J. Biol. Chem. 2003
Participants
Input
Output
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as an event of
Catalyst Activity

aminoacylase activity of ACY3:Zn2+ dimer [cytosol]

Physical Entity
ACY3:Zn2+ dimer [cytosol] (Homo sapiens)
Activity
aminoacylase activity (GO:0004046)
Orthologous Events
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Danio rerio)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Mus musculus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Rattus norvegicus)
ACY3:Zn2+ dimer hydrolyses mercapturic acids (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2014-05-12)
Reviewed
D'Eustachio, P  (2014-05-22)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2019-02-25)
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