Reactome | MIA2 [endoplasmic reticulum membrane]

MIA2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9637821

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

fullName evidence="21"Melanoma inhibitory activity protein 2, MIA2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q92633 LPAR1

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        MIA2 binds PREB (Homo sapiens)
        
        MIA2 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PC5 MIA2

Gene Names

MIA2, CTAGE5, MEA11, MEA6, MGEA11, MGEA6

Chain

signal peptide:1-19, chain:20-1412

Reference Genes

BioGPS Gene:4253 MIA2

COSMIC (genes):MIA2 MIA2

CTD Gene:4253 MIA2

dbSNP Gene:4253 MIA2

ENSEMBL:ENSG00000150527 CTAGE5

ENSEMBL_homo_sapiens_GENE:ENSG00000150527.18 MIA2

HGNC:18432 MIA2

KEGG Gene (Homo sapiens):4253 MIA2

Monarch:4253 MIA2

NCBI Gene:4253 MIA2

OMIM:602132 MIA2

UCSC:Q96PC5 MIA2

Reference Transcript

Other Identifiers

11731056_a_at

11731874_x_at

11737965_at

11755659_x_at

11759858_at

1228_s_at

1553944_PM_at

1553944_at

16783662

204055_PM_s_at

204055_s_at

215930_PM_s_at

215930_s_at

221177_PM_at

221177_at

3533486

3533487

3533488

3533489

3533490

3533491

3533493

3533494

3533495

3533496

3533497

3533498

3533500

3533501

3533504

3533505

3533506

3533507

3533508

3533509

3533510

3533515

3533516

3533518

3533520

3533521

3533522

3533524

3533525

3533527

3533528

3533529

3533530

3533531

3533533

3533534

3533535

3533536

3533538

3533539

3533541

3533543

3533547

3533548

3533549

3533550

3533551

3533559

3533560

3533565

41615_at

4253

7974080

7974090

A_14_P109745

A_14_P113093

A_14_P116503

A_14_P120479

A_14_P139658

A_23_P117387

A_23_P128773

A_32_P121362

A_33_P3246017

GE83057

GO:0005515

GO:0005783

GO:0005789

GO:0006886

GO:0006888

GO:0006897

GO:0008047

GO:0009306

GO:0016020

GO:0016192

GO:0032527

GO:0035459

GO:0038024

GO:0042953

GO:0043226

GO:0070971

GO:0070973

GO:0098772

HMNXSV003006673

HMNXSV003015815

HMNXSV003017094

Hs.117242.1.A1_3p_a_at

Hs2.350568.1.S1_3p_at

ILMN_1656743

ILMN_1662914

ILMN_1690880

ILMN_1754956

ILMN_2158665

ILMN_2314080

PH_hs_0014900

PH_hs_0028418

PH_hs_0041070

TC14002295.hg

TC14002296.hg

U73682_at

g13376567_3p_at

g5174560_3p_a_at

Participates

as an input of

MIA2 binds PREB (Homo sapiens)

as a component of

Inferred To

Mia2 [endoplasmic reticulum membrane] (Mus musculus)

Mia2 [endoplasmic reticulum membrane] (Rattus norvegicus)

Ghost homologue of MIA2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

MIA2 [endoplasmic reticulum membrane] (Bos taurus)

MIA2 [endoplasmic reticulum membrane] (Canis familiaris)

MIA2 [endoplasmic reticulum membrane] (Gallus gallus)

MIA2 [endoplasmic reticulum membrane] (Sus scrofa)

Tango1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_473365.3, NP_001316143.1, NP_976231.1, NP_001234919.1, XP_016876814.1, XP_011535087.1, NP_976229.1, NP_001234917.1, XP_016876809.1, XP_011535086.1, XP_006720211.1, NP_001234918.1, NP_005921.2

OpenTargets

ENSG00000150527

GeneCards

Q96PC5

HPA

ENSG00000150527-MIA2

Ensembl

ENSP00000280082, ENST00000280083, ENST00000280082, ENST00000348007, ENSP00000450449, ENSP00000450869, ENSP00000452562, ENST00000640607, ENST00000341749, ENST00000557038, ENSP00000339286, ENST00000556148, ENSP00000343912, ENSG00000150527, ENSP00000379462, ENSP00000491014, ENST00000553352, ENST00000341502, ENSP00000280083, ENSP00000379468, ENST00000396165, ENSP00000343897, ENST00000396158

PRO

Q96PC5

Pharos - Targets

Q96PC5

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75177 SS18L1	1	SS18L1 [nucleoplasm] (R-HSA-9727481)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q9Y6C2 EMILIN1	1	EMILIN1 [extracellular region] (R-HSA-2161355)	0.556	3
UniProt:Q96M61 MAGBI			0.556	3
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.556	3
UniProt:Q6PF05-3 TTC23L			0.556	3
UniProt:Q86XR8 CEP57	1	CEP57 [cytosol] (R-HSA-380271)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.556	3
UniProt:Q53EZ4 CEP55			0.527	2
UniProt:Q9NRK6 ABCB10	1	ABCB10 [mitochondrial inner membrane] (R-HSA-1369015)	0.527	2
UniProt:Q96RT6 CTGE2			0.527	2
UniProt:P18846 ATF1	2	ATF1 [nucleoplasm] (R-HSA-199900) p-S63-ATF1 [nucleoplasm] (R-HSA-199897)	0.527	2
UniProt:A6NKT7 RGPD3			0.527	2
UniProt:Q86X83 COMMD2	2	COMMD2 [nucleoplasm] (R-HSA-8955099) COMMD2 [cytosol] (R-HSA-8955112)	0.527	2
UniProt:Q16625 OCLN	4	OCLN [cell junction] (R-HSA-2160944) OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN [plasma membrane] (R-HSA-351846)	0.527	2
UniProt:O14715 RGPD8			0.527	2
UniProt:O60826 CCDC22	2	CCDC22 [nucleoplasm] (R-HSA-8955644) CCDC22 [cytosol] (R-HSA-8955640)	0.527	2
UniProt:Q15390 MTFR1			0.527	2
UniProt:Q92633 LPAR1	1	LPAR1 [plasma membrane] (R-HSA-419354)	0.527	2
UniProt:Q99666 RGPD5			0.527	2
UniProt:Q9BUZ4 TRAF4			0.527	2
UniProt:P14735 IDE	5	IDE [mitochondrial outer membrane] (R-HSA-5696861) PolyUb-IDE [mitochondrial outer membrane] (R-HSA-6783095) IDE [peroxisomal matrix] (R-HSA-9033157) IDE [cytosol] (R-HSA-9033133) IDE [endosome lumen] (R-HSA-9794504)	0.527	2
UniProt:Q4KMQ2 ANO6	3	ANO6 [specific granule membrane] (R-HSA-6799509) ANO6 [plasma membrane] (R-HSA-2684941) ANO6 [tertiary granule membrane] (R-HSA-6800903)	0.527	2
UniProt:Q9UBI1 COMMD3	4	COMMD3 [nucleoplasm] (R-HSA-8955108) COMMD3 [cytosol] (R-HSA-8955113) COMMD3 [extracellular region] (R-HSA-6806501) COMMD3 [ficolin-1-rich granule lumen] (R-HSA-6801405)	0.527	2
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	2

Cite Us!