SapM binds RAB7A

Stable Identifier
R-HSA-9636564
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol, phagocytic vesicle membrane
ReviewStatus
5/5
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SapM binds RAB7A
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Mtb phosphatidylinositol-3-phosphatase (SapM) blocks autophagosome-lysosome fusion in macrophages by binding to the human ras related protein Rab-7a (RAB7) (Hu et.al 2015).

Literature References
PubMed ID Title Journal Year
25896765 Autophagy regulation revealed by SapM-induced block of autophagosome-lysosome fusion via binding RAB7

Xiao, J, Zhang, R, Xu, X, Mu, M, Yang, Y, Wang, W, Hu, D, Wu, J, Zhao, R, Hu, F, Chen, Z

Biochem. Biophys. Res. Commun. 2015
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-13)
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