Eis acetylates DUSP16

Stable Identifier
R-HSA-9636560
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mtb N-acetyltransferase Eis (Eis) acts as an N-acetyltransferase to acetylate lysine at coordinate 55 within the docking domain of the human dual specificity protein phosphatase 16 (DUSP16). This acetylation significantly down-regulates the phosphorylation of c-Jun N-terminal kinase (JNK) (Kim et al. 2012).

Literature References
PubMed ID Title Journal Year
22547814 Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

Kim, KH, An, DR, Song, J, Yoon, JY, Kim, HS, Yoon, HJ, Im, HN, Kim, J, Kim, DJ, Lee, SJ, Kim, KH, Lee, HM, Kim, HJ, Jo, EK, Lee, JY, Suh, SW

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N-acetyltransferase activity of Eis [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
Cite Us!