NEIL3 resolves abasic site-induced ICLs

Stable Identifier
R-HSA-9636008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on studies in Xenopus, NEIL3 is able to resolve abasic site-induced interstrand crosslinks (AP-ICLs), that form when an aldehyde group of the AP site reacts with the amine of a nucleic acid base, usually adenine, on the opposite strand. NEIL3-mediated unhooking of AP-ICLs is independent of the Fanconi anemia (FA) pathway (Semlow et al. 2016).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL3 [nucleoplasm]
Physical Entity
Activity
Inferred From
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