Expression of TRIB3 in response to stress

Stable Identifier
R-HSA-9635912
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of TRIB3 in response to stress
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The TRIB3 (TRB3, NIPK) gene is transcribed to yield mRNA and the mRNA is translated to yield TRIB3 protein (Ohoka et al. 2005, Ord and Ord 2005, Lee et al. 2008, Sikalidis et al. 2011, Ord et al. 2016, and inferred from the mouse homolog). Transcription of TRIB3 is enhanced in response to amino acid deficiency (Lee et al. 2008, Sikalidis et al. 2011, and inferred from mouse homologs), endoplasmic reticulum stress (Ohoka et al. 2005, Ord and Ord 2005), oxidative stress (Ord and Ord 2005, Ord et al. 2016) and heme deficiency (inferred from mouse homologs). ATF4 bound with a CEBP family protein to the promoter of TRIB3 (NIPK, TRB3) enhances transcription of TRIB3 (Ohoka et al. 2005, Ord and Ord 2005, Lee et al. 2008, Sikalidis et al. 2011, Ord et al. 2016, and inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
27526673 TRIB3 increases cell resistance to arsenite toxicity by limiting the expression of the glutathione-degrading enzyme CHAC1

Örd, T, Biene, T, Ord, T, Ord, D

Biochim. Biophys. Acta 2016
18285520 HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway

Dominy, JE, Sikalidis, AK, Lee, JI, Stipanuk, MH, Hirschberger, LL, Wang, W

Physiol. Genomics 2008
15781252 Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions

Ord, T, Ord, D

Biochem. Biophys. Res. Commun. 2005
20361218 Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

Sikalidis, AK, Lee, JI, Stipanuk, MH

Amino Acids 2011
15775988 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

Yoshii, S, Hattori, T, Onozaki, K, Ohoka, N, Hayashi, H

EMBO J. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ATF4:CEBPB,CEBPG,DDIT3:TRIB3 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Trib3 (Mus musculus)
Authored
May, B  (2019-02-09)
Reviewed
Staschke, KA  (2019-11-20)
Chen, JJ  (2019-10-22)
Bruhat, A  (2019-09-15)
Created
May, B  (2019-02-10)
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