Reactome | TRIB3 [nucleoplasm]

TRIB3 [nucleoplasm]

Stable Identifier

R-HSA-9635877

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Tribbles homolog 3, TRIB3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q96SQ5 ZNF587

Expand all

Literature References

PubMed ID	Title	Journal	Year
17112672	TRB3 interacts with CtIP and is overexpressed in certain cancers Xu, Y, Xu, BE, Lv, S, Wu, J, Shu, F, Xu, J, Qin, Y, Sun, X, Chen, J	Biochim. Biophys. Acta	2007
25845379	Tribbles homolog 3 is induced by high glucose and associated with apoptosis in human endothelial cells Guo, ZX, Zhang, Y, Shang, YY, Zhong, M, Gong, HP, Zhang, W, Guo, L	Mol Med Rep	2015
21896644	TRB3 interacts with SMAD3 promoting tumor cell migration and invasion Hu, Z, Yang, H, Chen, X, Xue, J, Wang, Z, Lin, H, Hua, F, Mu, R, Liu, J	J. Cell. Sci.	2011

External Reference Information

External Reference

UniProt:Q96RU7 TRIB3

Gene Names

TRIB3, C20orf97, NIPK, SKIP3, TRB3

Chain

chain:1-358

Reference Genes

BioGPS Gene:57761 TRIB3

COSMIC (genes):TRIB3 TRIB3

CTD Gene:57761 TRIB3

dbSNP Gene:57761 TRIB3

ENSEMBL:ENSG00000101255 TRIB3

ENSEMBL_homo_sapiens_GENE:ENSG00000101255.12 TRIB3

HGNC:16228 TRIB3

KEGG Gene (Homo sapiens):57761 TRIB3

Monarch:57761 TRIB3

NCBI Gene:57761 TRIB3

OMIM:607898 TRIB3

UCSC:Q96RU7 TRIB3

Reference Transcript

Other Identifiers

11719811_a_at

11751172_a_at

1555788_PM_a_at

1555788_a_at

16910609

218145_PM_at

218145_at

3873165

3873166

3873167

3873168

3873172

3873173

3873174

3873175

3873176

3873177

3873178

3873179

3873180

3873181

3873182

51141_at

57761

8060344

83485_at

A_23_P210690

A_24_P305541

GE82597

GO:0000122

GO:0003714

GO:0003824

GO:0004672

GO:0004860

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006469

GO:0006629

GO:0006914

GO:0006915

GO:0010506

GO:0010827

GO:0012501

GO:0016740

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0030163

GO:0031434

GO:0031625

GO:0032092

GO:0032436

GO:0032869

GO:0034976

GO:0036211

GO:0043226

GO:0043405

GO:0045599

GO:0045717

GO:0045892

GO:0051443

GO:0055085

GO:0055106

GO:0070059

GO:0098772

GO:0140096

GO:0140110

HMNXSV003014913

Hs2.26802.3.S1_3p_s_at

ILMN_1787815

PH_hs_0023894

TC20000009.hg

g11056039_3p_at

Participates

as an output of

as a component of

TRIB3:CHAC1 gene [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TRIB3 [plasma membrane]

TRIB3 [cytosol]

Cross References

RefSeq

NP_066981.2, NP_001288119.1, NP_001288130.1, NP_001288122.1, NP_001288125.1, NP_001288117.1

Guide to Pharmacology - Targets

2251

OpenTargets

ENSG00000101255

HPA

ENSG00000101255-TRIB3

GeneCards

Q96RU7

Ensembl

ENST00000217233, ENSP00000217233, ENSG00000101255

PRO

Q96RU7

Pharos - Targets

Q96RU7

Interactors (77)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.9	16
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.666	4
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.666	7
UniProt:Q8N2I9 STK40			0.643	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.61	4
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q96KN7 RPGR1			0.556	3
UniProt:Q0VAL7 Q0VAL7			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.556	3
UniProt:Q96KN3 PKNX2			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q9BRU9 UTP23			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q96NU1 SAM11			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
IntAct:EBI-22315148 CCSB ORF ID			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:O15197-2 EPHB6			0.556	3
UniProt:Q9Y242 TCF19			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.556	3
UniProt:Q7Z3Y9 KRT26	1	KRT26 [cytosol] (R-HSA-6809593)	0.556	3
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q5T8A7 PPR26			0.556	3
UniProt:Q6P5X5 CV039			0.556	3
UniProt:Q96KN7-4 RPGRIP1			0.556	3
UniProt:Q99697-2 PITX2			0.556	3
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.556	3
UniProt:P78358 CTG1B			0.556	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.556	3
UniProt:Q9H6L4 ARMC7			0.556	3
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q6NZ36-4 FAAP20			0.556	3
UniProt:Q9NWQ4-1 GPATCH2L			0.556	3
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.556	3
UniProt:Q9BXF9 TEKT3			0.556	3
UniProt:P51800-3 CLCNKA			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:P56524-2 HDAC4			0.556	3
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:Q13515 BFSP2			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:A6NJB7-2 PRR19			0.556	3
UniProt:Q13111 CAF1A			0.556	5
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q14005-2 Q140052			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q8WUN7 UBTD2			0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q8WW24 TEKT4			0.556	5
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	3
UniProt:P31273 HOXC8	1	HOXC8 [nucleoplasm] (R-HSA-3222311)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	5
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q9UM07 PADI4	2	PADI4 [cytosol] (R-HSA-1183117) PADI4 [nucleoplasm] (R-HSA-6793448)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q8NEA6-2 GLIS3			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q9NUL5-4 SHFL			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q2WGJ6 KLH38			0.556	3
UniProt:P78412 IRX6			0.556	3
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [nucleoplasm] (R-HSA-349450) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [cytosol] (R-HSA-349439)	0.527	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.508	2

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