ATF4 and phospho-ATF2 bind the DDIT3 promoter

Stable Identifier
R-HSA-9635804
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The promoter of the DDIT3 (CHOP) gene contains an Amino Acid Response Element (AARE) that binds ATF4 and ATF2. ATF2 and ATF4 are required for full activation of gene transcription in response to amino acid deprivation (Bruhat et al. 2000, Averous et al. 2004). Phospho-ATF2 is essential in the acetylation of histone H4 and H2B (Bruhat et al. 2007). ATF4 recruits PCAF to enhance transcription (Chérasse et al. 2007). ATF4 appears to be a monomer in the absence of DNA and a dimer after binding DNA (Podust et al. 2001).

Literature References
PubMed ID Title Journal Year
14630918 Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

Averous, J, Bruhat, A, Jousse, C, Carraro, V, Thiel, G, Fafournoux, P

J Biol Chem 2004
17267404 ATF2 is required for amino acid-regulated transcription by orchestrating specific histone acetylation

Bruhat, A, Cherasse, Y, Maurin, AC, Breitwieser, W, Parry, L, Deval, C, Jones, N, Jousse, C, Fafournoux, P

Nucleic Acids Res. 2007
17726049 The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP

Cherasse, Y, Maurin, AC, Chaveroux, C, Jousse, C, Carraro, V, Parry, L, Deval, C, Chambon, C, Fafournoux, P, Bruhat, A

Nucleic Acids Res. 2007
10982836 Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter

Bruhat, A, Jousse, C, Carraro, V, Reimold, AM, Ferrara, M, Fafournoux, P

Mol. Cell. Biol. 2000
11018027 Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA

Podust, LM, Krezel, AM, Kim, Y

J. Biol. Chem. 2001
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