Reactome | PTPN7 binds p-T,Y-MAPK

PTPN7 binds p-T,Y-MAPK

Stable Identifier

R-HSA-9635743

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PTPN7 binds phosphorylated ERKs

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PTPN7 (HePTP) protein tyrosine phosphatase binds to MAPK1 (ERK2) (Saxena et al. 1999, Munoz et al. 2003) and MAPK3 (ERK1) (Oh-hora et al. 1999, Munoz et al. 2003). The interaction of PTPN7 with MAPKs involves the KIM (kinase-interaction motif) of PTPN7.
PTPN7 may have a preference for ERK2 over ERK1 (Pettiford and Herbst 2000). ERK1 used in the study by Oh-hora et al. 1999 was likely human, but it is not certain. In the study by Munoz et al. 2003, interaction of PTPN7 with rat ERK1 was demonstrated, but the origin of PTPN7 was not specified.

Literature References

PubMed ID	Title	Journal	Year
10415025	Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase Oh-hora, M, Ogata, M, Mori, Y, Adachi, M, Imai, K, Kosugi, A, Hamaoka, T	J. Immunol.	1999
10702794	The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP Pettiford, SM, Herbst, R	Oncogene	2000
12583813	Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents Muñoz, JJ, Tárrega, C, Blanco-Aparicio, C, Pulido, R	Biochem. J.	2003
10206983	Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP) Saxena, M, Williams, S, Brockdorff, J, Gilman, J, Mustelin, T	J. Biol. Chem.	1999

Participants

Input

Output

PTPN7:p-T,Y-MAPK dimers [cytosol] (Homo sapiens)

Participant Of

hasEvent

Negative regulation of MAPK pathway

Orthologous Events

PTPN7 binds p-T,Y-MAPK (Bos taurus)

PTPN7 binds p-T,Y-MAPK (Canis familiaris)

PTPN7 binds p-T,Y-MAPK (Danio rerio)

PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)

PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)

PTPN7 binds p-T,Y-MAPK (Mus musculus)

PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)

Authored

Orlic-Milacic, M (2019-09-23)

Rothfels, K (2019-10-28)

Reviewed

Gavathiotis, E (2020-05-04)

Created

Orlic-Milacic, M (2019-02-08)