PTPN7 binds p-T,Y-MAPK

Stable Identifier
R-HSA-9635743
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PTPN7 binds phosphorylated ERKs
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PTPN7 binds p-T,Y-MAPK
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PTPN7 (HePTP) protein tyrosine phosphatase binds to MAPK1 (ERK2) (Saxena et al. 1999, Munoz et al. 2003) and MAPK3 (ERK1) (Oh-hora et al. 1999, Munoz et al. 2003). The interaction of PTPN7 with MAPKs involves the KIM (kinase-interaction motif) of PTPN7.
PTPN7 may have a preference for ERK2 over ERK1 (Pettiford and Herbst 2000). ERK1 used in the study by Oh-hora et al. 1999 was likely human, but it is not certain. In the study by Munoz et al. 2003, interaction of PTPN7 with rat ERK1 was demonstrated, but the origin of PTPN7 was not specified.

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Orthologous Events
PTPN7 binds p-T,Y-MAPK (Bos taurus)
PTPN7 binds p-T,Y-MAPK (Caenorhabditis elegans)
PTPN7 binds p-T,Y-MAPK (Canis familiaris)
PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)
PTPN7 binds p-T,Y-MAPK (Drosophila melanogaster)
PTPN7 binds p-T,Y-MAPK (Mus musculus)
PTPN7 binds p-T,Y-MAPK (Rattus norvegicus)
PTPN7 binds p-T,Y-MAPK (Saccharomyces cerevisiae)
PTPN7 binds p-T,Y-MAPK (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2019-09-23)
Rothfels, K  (2019-10-28)
Reviewed
Gavathiotis, E  (2020-05-04)
Created
Orlic-Milacic, M  (2019-02-08)
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