Rv3364c binds cathepsin G

Stable Identifier
R-HSA-9635424
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Rv3364c binds cathepsin G
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Mtb secretes serine protease inhibitor Rv3364c (Rv3364c) protein into the phagocyte's cytosol which blocks the serine protease activity of human cathepsin G (CTSG), inhibiting the cleavage of caspase-1 (Danelishvili et al. 2011).

Literature References
PubMed ID Title Journal Year
22275911 Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages

Everman, JL, McNamara, MJ, Danelishvili, L, Bermudez, LE

Front Microbiol 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-12)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Pardo, AM  (2019-02-05)
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