Rv3364c binds cathepsin G

Stable Identifier
R-HSA-9635424
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Mtb secretes serine protease inhibitor Rv3364c (Rv3364c) protein into the phagocyte's cytosol which blocks the serine protease activity of human cathepsin G (CTSG), inhibiting the cleavage of caspase-1 (Danelishvili et al. 2011).

Literature References
PubMed ID Title Journal Year
22275911 Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages

Danelishvili, L, Everman, JL, McNamara, MJ, Bermudez, LE

Front Microbiol 2011
Participants
Participant Of
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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