NPAS4 binds CDK5R1 gene promoter

Stable Identifier
R-HSA-9634897
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 binds CDK5R1 gene promoter
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Based on mouse studies, NPAS4 binds the promoter of the CDK5R1 gene, encoding p35, a neuron-specific activator of CDK5 (Yun et al. 2013). It is uncertain whether NPAS4 heterodimerized with ARNT, ARNT2 or ARNTL binds to the CDK5R1 gene promoter. Therefore, all three complexes (NPAS4:ARNT, NPAS4:ARNT2 and NPAS4:ARNTL) are shown as candidates. In rat primary neurons, Npas4, Arnt and Arnt2 bind to the Cdk5r1 gene promoter and Cdk5r1 gene transcription is significantly upregulated upon Npas4 activation (Brigidi et al. 2019).
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Npas4 binds Cdk5r1 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-01-16)
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