NPAS4 binds RBFOX3 (NeuN) gene promoter

Stable Identifier
R-HSA-9634886
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Based on studies in mouse neurons, NPAS4 binds the promoter of the RBFOX3 gene, encoding NeuN, a marker of mature, post-mitotic neurons (Yun et al. 2013). NPAS4 needs to heterodimerize with another basic helix-loop-helix (bHLH) transcription factor in order to bind target DNA. Known NPAS4 heterodimerization partners include members of the aryl hydrocarbon receptor nuclear transclocator (ARNT) family: ARNT (Ooe et al. 2004), ARNT2 (Ooe et al. 2004, Bersten et al. 2014) and ARNTL (BMAL1) (Ooe et al. 2004). ARNTL (BMAL1) positively regulates NeuN expression (Malik et al. 2015). Therefore, NPAS4:ARNT, NPAS4:ARNT2 and NPAS4:ARNTL heterodimers are annotated as candidate complexes that bind NeuN gene promoter. In primary cultures of rat neurons, Npas4, Arnt, and Arnt2 were shown to bind to multiple regions of the Rbfox3 gene, both intron 1 and intergenic (Brigidi et al. 2019).
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