LINC01139 promotes phosphorylation of HIF1A by LRRK2

Stable Identifier
R-HSA-9634702
Type
Reaction
Species
Homo sapiens
Compartment
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LRRK2 serine/threonine kinase, activated via long non-coding RNA LINC01139 (LINK-A) mediated recruitment to phosphorylated GPNMB (bound to HBEGF-activated EGFR), phosphorylates hypoxia inducible factor 1 alpha (HIF1A) at serine residue S797. LRRK2-mediated phosphorylation of HIF1A at S797 promotes association of HIF1A with EP300 (p300) transcriptional co-activator and inhibits association of HIF1A with a transactivation inhibitor HIF1AN (FIH) (Lin et al. 2016).

Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH

Nat. Cell Biol. 2016
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Catalyst Activity

protein serine/threonine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane]

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