CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SPI1 (PU.1) and CEBPA bind the promoter of the CSF3R (G-CSFR) gene and synergistically activate transcription of CSF3R (Smith et al. 1996, Tavor et al. 2003). Absence of CEBPA binding reduces transcription by about 60% and absence of SPI1 binding reduces transcription by about 75% (Smith et al. 1996). DEK interacts with CEBPA at the CSF3R promoter and enhances transcription (Koleva et al. 2012). DEK is required for CSF3 (G-CSF) mediated granulocyte differentiation (Koleva et al. 2012).

Literature References
PubMed ID Title Journal Year
14517214 Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation

Vuong, PT, Gery, S, Park, DJ, Gombart, AF, Koeffler, HP, Tavor, S

J. Biol. Chem. 2003
8695841 PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells

Dziennis, SE, Gonzalez, DA, Smith, LT, Tenen, DG, Hohaus, S

Blood 1996
22474248 C/EBPα and DEK coordinately regulate myeloid differentiation

Marto, JA, Webber, JT, Alberta, JA, Carrasco-Alfonso, MJ, Radomska, HS, Marcucci, G, Ficarro, SB, Koleva, RI, Tenen, DG, Luckey, CJ

Blood 2012
This event is regulated
Inferred From
Cite Us!