PTK2 is recruited to methylated ESR1

Stable Identifier
R-HSA-9632412
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PTK2 (also known as FAK) is co-immunoprecipitated with methylated ESR1 and PI3K after stimulation with estrogen. This interaction depends on ESR1 methylation and on SRC activity, as it is abrogated in the presence of SRC inhibitors or upon PRMT1 depletion (Le Romancer et al, 2008). Phosphorylation of PTK2 appears to be dynamic, as it is lost within 15 minutes of estrogen stimulation, promoting disassembly of the complex. Interaction with PTK2 may contribute to estrogen-stimulated cell motility.

Literature References
PubMed ID Title Journal Year
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1

Le Romancer, M, Treilleux, I, Leconte, N, Robin-Lespinasse, Y, Sentis, S, Bouchekioua-Bouzaghou, K, Goddard, S, Gobert-Gosse, S, Corbo, L

Mol. Cell 2008
Participants
Participant Of
Orthologous Events
Authored
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Created