PRMT1 methylates ESRs

Stable Identifier
Reaction [transition]
Homo sapiens
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ESR1 is methylated by PRMT1 at arginine 260 in response to E2 stimulation. Methylation is required for rapid non-genomic signaling by E2 and promotes the interaction of ESR1 with the p85 regulatory subunit of PI3K, SRC and PTK2 (FAK) (Simoncini et al, 2000; Le Romancer, 2008; reviewed in Arnal, 2017). Although this reaction is shown preceding palmitoylation of ESR1, the sequence of these two events is not established.
Literature References
PubMed ID Title Journal Year
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, M├ętivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
11029009 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Liao, JK, Brazil, DP, Ley, K, Hafezi-Moghadam, A, Simoncini, T, Chin, WW

Nature 2000
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1

Leconte, N, Robin-Lespinasse, Y, Gobert-Gosse, S, Bouchekioua-Bouzaghou, K, Goddard, S, Corbo, L, Sentis, S, Treilleux, I, Le Romancer, M

Mol. Cell 2008
Catalyst Activity

protein methyltransferase activity of PRMT1 [cytosol]

This event is regulated
Positively by
Orthologous Events
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