PRMT1 methylates ESRs

Stable Identifier
R-HSA-9632182
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ESR1 is methylated by PRMT1 at arginine 260 in response to E2 stimulation. Methylation is required for rapid non-genomic signaling by E2 and promotes the interaction of ESR1 with the p85 regulatory subunit of PI3K, SRC and PTK2 (FAK) (Simoncini et al, 2000; Le Romancer, 2008; reviewed in Arnal, 2017). Although this reaction is shown preceding palmitoylation of ESR1, the sequence of these two events is not established.

Literature References
PubMed ID Title Journal Year
11029009 Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

Simoncini, T, Hafezi-Moghadam, A, Brazil, DP, Ley, K, Chin, WW, Liao, JK

Nature 2000
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Arnal, JF, Lenfant, F, M├ętivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J

Physiol. Rev. 2017
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1

Le Romancer, M, Treilleux, I, Leconte, N, Robin-Lespinasse, Y, Sentis, S, Bouchekioua-Bouzaghou, K, Goddard, S, Gobert-Gosse, S, Corbo, L

Mol. Cell 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein methyltransferase activity of PRMT1 [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created