UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG

Stable Identifier
R-HSA-9632039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP
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Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 and 4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992). Mutations of the UGT1A1 gene cause complete loss or partial activity for bilirubin glucuronidation.

Literature References
PubMed ID Title Journal Year
8027054 Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man

Bosma, PJ, Seppen, J, Goldhoorn, B, Bakker, C, Oude, Elferink R, Chowdhury, JR, Chowdhury, NR, Jansen, PL

J Biol Chem 1994
1339448 A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

Ritter, JK, Chen, F, Sheen, YY, Tran, HM, Kimura, S, Yeatman, MT, Owens, IS

J. Biol. Chem. 1992
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Event Information
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Catalyst Activity
Catalyst Activity
Title
glucuronosyltransferase activity of UGT1A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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