UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG

Stable Identifier
R-HSA-9632039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP
ReviewStatus
5/5
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UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG
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Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 tetramer and UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992, Peters & Jansen 1986, Gorden et al. 1983, Choudhury et al. 1981, Fevery et al. 1971).

Literature References
PubMed ID Title Journal Year
1339448 A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

Owens, IS, Chen, F, Ritter, JK, Kimura, S, Sheen, YY, Yeatman, MT, Tran, HM

J. Biol. Chem. 1992
8027054 Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man

Goldhoorn, B, Bosma, PJ, Jansen, PL, Oude, Elferink R, Bakker, C, Seppen, J, Chowdhury, JR, Chowdhury, NR

J Biol Chem 1994
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
bilirubin conjugation (0006789)
Catalyst Activity

glucuronosyltransferase activity of UGT1A1 [endoplasmic reticulum membrane]

Physical Entity
UGT1A1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glucuronosyltransferase activity (GO:0015020)
Orthologous Events
UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Gallus gallus)
UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Mus musculus)
UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG (Rattus norvegicus)
Authored
Jassal, B  (2005-02-23)
Reviewed
D'Eustachio, P  (2010-05-08)
Created
Jassal, B  (2018-12-13)
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