Reactome | UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG

UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG

Stable Identifier

R-HSA-9632039

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

bilirubin + UDP-glucuronic acid => bilirubin monoglucuronide + UDP

ReviewStatus

5/5

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UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG

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Bilirubin (BIL) is a breakdown product of heme. Its accumulation in the blood can be fatal. It is highly lipophilic and thus requires conjugation to become more water soluble to aid excretion. Both UGT1A1 tetramer and UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin to form either its monoglucuronide (BMG) or diglucuronide (BDG) conjugates (Bosma et al. 1994, Ritter et al. 1992, Peters & Jansen 1986, Gorden et al. 1983, Choudhury et al. 1981, Fevery et al. 1971).

Literature References

PubMed ID	Title	Journal	Year
1339448	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini Owens, IS, Chen, F, Ritter, JK, Kimura, S, Sheen, YY, Yeatman, MT, Tran, HM	J. Biol. Chem.	1992
8027054	Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man Goldhoorn, B, Bosma, PJ, Jansen, PL, Oude, Elferink R, Bakker, C, Seppen, J, Chowdhury, JR, Chowdhury, NR	J Biol Chem	1994