HSPA8:substrate binds late endosomal phospholipids

Stable Identifier
R-HSA-9631068
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Microautophagy (MI) can target KFERQ motif containing protein substrates to endosomal degradation. Upon binding with HSPA8, substrates are transported from the cytosol to late endosomes. Here, HSPA8 binds with the phospholipids on the late endosomal membrane. This interaction facilitates the vesicle-mediated transport of HSPA8:substrate complex into the late endosomes for degradation (Sahu R et al. 2011). Experiments confirming this interaction were performed in mouse cells.

Literature References
PubMed ID Title Journal Year
21238931 Microautophagy of cytosolic proteins by late endosomes

Sahu, R, Kaushik, S, Clement, CC, Cannizzo, ES, Scharf, B, Follenzi, A, Potolicchio, I, Nieves, E, Cuervo, AM, Santambrogio, L

Dev. Cell 2011
Participants
Participant Of
Inferred From
Authored
Reviewed
Created