PDE3A,3B hydrolyses cAMP to AMP

Stable Identifier
R-HSA-9629675
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3 inhibition promotes cardiac muscle contraction, a strategy used in heart failure.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3',5'-cyclic-AMP phosphodiesterase activity of PDE3A,3B [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created