PDE3A hydrolyses cAMP to AMP

Stable Identifier
R-HSA-9629675
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PDE3A hydrolyses cAMP to AMP
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Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP (Maurice 2005). PDEs are important as drug targets:PDE3A inhibition promotes cardiac muscle contraction, a strategy used in heart failure.
Literature References
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Catalyst Activity

3',5'-cyclic-AMP phosphodiesterase activity of PDE3A [cytosol]

Physical Entity
PDE3A [cytosol] (Homo sapiens)
Activity
3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115)
Orthologous Events
PDE3A hydrolyses cAMP to AMP (Bos taurus)
PDE3A hydrolyses cAMP to AMP (Caenorhabditis elegans)
PDE3A hydrolyses cAMP to AMP (Canis familiaris)
PDE3A hydrolyses cAMP to AMP (Dictyostelium discoideum)
PDE3A hydrolyses cAMP to AMP (Gallus gallus)
PDE3A hydrolyses cAMP to AMP (Mus musculus)
PDE3A hydrolyses cAMP to AMP (Plasmodium falciparum)
PDE3A hydrolyses cAMP to AMP (Rattus norvegicus)
PDE3A hydrolyses cAMP to AMP (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2018-11-23)
Jupe, S  (2009-04-23)
Reviewed
Varusai, TM  (2017-07-10)
Akkerman, JW  (2009-06-03)
Created
Jassal, B  (2018-11-23)
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