NEIL3 cleaves thymine glycol from telomeric DNA

Stable Identifier
R-HSA-9629497
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL3 cleaves oxidatively damaged thymine in the form of thymine glycol (Tg) from telomeric DNA, producing an abasic (AP) site (Zhou et al. 2013). NEIL3 prefers Tg damages in telomeric DNA over random sequences.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm]
Physical Entity
Activity
Inferred From
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