NEIL3 cleaves spiroiminodihydantoin

Stable Identifier
R-HSA-9629492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL3 cleaves spiroiminodihydantoin
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NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing an abasic (AP) site (Krokeide et al. 2013). The preference of NEIL3 for ssDNA was structurally explained using mouse Neil3 (Liu et al. 2013).
Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Salah, M, Dalhus, B, Cederkvist, FH, Bjørås, M, Burrows, CJ, Luna, L, Laerdahl, JK, Fleming, AM, Krokeide, SZ

DNA Repair (Amst.) 2013
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Catalyst Activity

DNA N-glycosylase activity of NEIL3:Sp-DNA [nucleoplasm]

Physical Entity
NEIL3:Sp-DNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL3 cleaves spiroiminodihydantoin (Bos taurus)
NEIL3 cleaves spiroiminodihydantoin (Canis familiaris)
NEIL3 cleaves spiroiminodihydantoin (Gallus gallus)
NEIL3 cleaves spiroiminodihydantoin (Mus musculus)
NEIL3 cleaves spiroiminodihydantoin (Rattus norvegicus)
NEIL3 cleaves spiroiminodihydantoin (Sus scrofa)
NEIL3 cleaves spiroiminodihydantoin (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Zhou, J  (2019-02-11)
Created
Orlic-Milacic, M  (2018-11-21)
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