NEIL3 cleaves spiroiminodihydantoin

Stable Identifier
R-HSA-9629492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing an abasic (AP) site (Krokeide et al. 2013). The preference of NEIL3 for ssDNA was structurally explained using mouse Neil3 (Liu et al. 2013).
Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Salah, M, Dalhus, B, Cederkvist, FH, Bjørås, M, Burrows, CJ, Luna, L, Laerdahl, JK, Fleming, AM, Krokeide, SZ

DNA Repair (Amst.) 2013
Participants
Participates
Catalyst Activity

DNA N-glycosylase activity of NEIL3:Sp-DNA [nucleoplasm]

Orthologous Events
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