NEIL3 cleaves spiroiminodihydantoin

Stable Identifier
R-HSA-9629492
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing an abasic (AP) site (Krokeide et al. 2013). The preference of NEIL3 for ssDNA was structurally explained using mouse Neil3 (Liu et al. 2013).

Literature References
PubMed ID Title Journal Year
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Krokeide, SZ, Laerdahl, JK, Salah, M, Luna, L, Cederkvist, FH, Fleming, AM, Burrows, CJ, Dalhus, B, Bjørås, M

DNA Repair (Amst.) 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL3:Sp-DNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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