NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA), producing an abasic (AP) site (Krokeide et al. 2013). The preference of NEIL3 for ssDNA was structurally explained using mouse Neil3 (Liu et al. 2013).
Salah, M, Dalhus, B, Cederkvist, FH, Bjørås, M, Burrows, CJ, Luna, L, Laerdahl, JK, Fleming, AM, Krokeide, SZ
DNA N-glycosylase activity of NEIL3:Sp-DNA [nucleoplasm]
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