NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA

Stable Identifier
R-HSA-9629483
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL3 cleaves oxidatively damaged guanine in the form of spiroiminodihydantoin (Sp) form telomeric DNA, leaving an abasic (AP) site (Zhou et al. 2013).

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Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm]
Physical Entity
Activity
Inferred From
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