NEIL3 recognizes and binds to spiroiminodihydantoin

Stable Identifier
R-HSA-9629365
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NEIL3 recognizes DNA damage in the form of guanine oxidized to spiroiminodihydantoin (Sp), with a preference for single-strand DNA (ssDNA) over double-strand DNA (dsDNA) (Liu et al. 2012, Krokeide et al. 2013).

Literature References
PubMed ID Title Journal Year
22569481 Expression and purification of active mouse and human NEIL3 proteins

Liu, M, Bandaru, V, Holmes, A, Averill, AM, Cannan, W, Wallace, SS

Protein Expr. Purif. 2012
23755964 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin

Krokeide, SZ, Laerdahl, JK, Salah, M, Luna, L, Cederkvist, FH, Fleming, AM, Burrows, CJ, Dalhus, B, Bjørås, M

DNA Repair (Amst.) 2013
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