NEIL1 G83D does not cleave FapyA

Stable Identifier
R-HSA-9628756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL1 G83D variant is a low frequency polymorphism, estimated to occur in ~1% of US population (Roy et al. 2007), and is associated with primary sclerosing cholangitis and cholangiocarcinoma (Forsbring et al. 2009). NEIL1 G83D does not cleave FapyA from damaged DNA (Roy at al. 2007).

Literature References
PubMed ID Title Journal Year
17389588 Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, LM, Jaruga, P, Wood, TG, McCullough, AK, Dizdaroglu, M, Lloyd, RS

J. Biol. Chem. 2007
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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