NEIL1 G83D does not cleave FapyA

Stable Identifier
R-HSA-9628756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL1 G83D does not cleave FapyA
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NEIL1 G83D variant is a low frequency polymorphism, estimated to occur in ~1% of US population (Roy et al. 2007), and is associated with primary sclerosing cholangitis and cholangiocarcinoma (Forsbring et al. 2009). NEIL1 G83D does not cleave FapyA from damaged DNA (Roy at al. 2007).
Literature References
PubMed ID Title Journal Year
17389588 Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, LM, Jaruga, P, Wood, TG, McCullough, AK, Dizdaroglu, M, Lloyd, RS

J. Biol. Chem. 2007
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as an event of
Normal reaction
NEIL1 cleaves FapyA from damaged DNA (Homo sapiens)
Functional status

Loss of function of NEIL1 G83D:FapyA-dsDNA [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2018-11-27)
Reviewed
Sampath, H  (2019-01-03)
Created
Orlic-Milacic, M  (2018-11-13)
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