Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, LAMP2a forms a multimeric complex and transfers the substrate into the lumen. The stability of this complex is regulated by the dynamics of Heat shock protein HSP 90 (HSP90) and HSPA8 (Bandyopadhyay U et al. 2008). HSPA8 and HSP90 dissociate from LAMP2a to make it available for further substrate autophagy. Experiments related to this event were performed in rats.
Cuervo, AM, Kaushik, S, Bandyopadhyay, U, Varticovski, L
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