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HSPA8 dissociates from LAMP2a
Stable Identifier
R-HSA-9626235
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
lysosomal membrane
ReviewStatus
5/5
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Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
HSPA8 dissociates from LAMP2a (Homo sapiens)
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Intracellular proteins are targeted for proteolytic degradation in lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (HSPA8) transports substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (LAMP2a). Subsequently, LAMP2a forms a multimeric complex and transfers the substrate into the lumen. The stability of this complex is regulated by the dynamics of HSPA8. Cytosolic HSPA8 binds with LAMP2a multimers in the lysosomal membrane and triggers their disassembly into monomeric units (Bandyopadhyay U et al. 2008). HSPA8 dissociates from LAMP2a to make it available for further substrate autophagy. Experiments related to this event were performed in rats.
Literature References
PubMed ID
Title
Journal
Year
18644871
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
Cuervo, AM
,
Kaushik, S
,
Bandyopadhyay, U
,
Varticovski, L
Mol. Cell. Biol.
2008
Participants
Input
HSPA8:LAMP2a multimers [lysosomal membrane]
(Homo sapiens)
Output
HSPA8 [cytosol]
(Homo sapiens)
LAMP2a:HSP90 [lysosomal membrane]
(Homo sapiens)
Participates
as an event of
Chaperone Mediated Autophagy (Homo sapiens)
Inferred From
Hspa8 dissociates from Lamp2 (Rattus norvegicus)
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-10-26)
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