Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine

Stable Identifier
R-HSA-9625904
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
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Hypochlorous acid (HOCL) reacts with Lys residue to form Lys-monochloramine
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Myeloperoxidase (MPO)-produced hypochlorous acid (HOCl) reacts with N-terminal amino acids and lysine (Lys) residues of proteins contained within phagosomes to form protein chloramines and dichloramines (Chapman ALP et al. 2002; Green JN et al. 2017). These species decompose to yield chlorimines, aldehydes, and the inorganic gases ammonia monochloramine (NH2Cl) and ammonia dichloramine (NHCl2) (Hazen S et al. 1998; Coker MS et al. 2008; Green JN et al. 2017). Cytotoxic NH2Cl and NHCl2 may contribute to killing of ingested bacteria (Coker MS et al. 2008; Green JN et al. 2017).

Literature References
PubMed ID Title Journal Year
29055823 Neutrophil granule proteins generate bactericidal ammonia chloramine on reaction with hydrogen peroxide

Green, JN, Chapman, ALP, Bishop, CJ, Winterbourn, CC, Kettle, AJ

Free Radic. Biol. Med. 2017
14661089 Hypochlorite-induced oxidation of amino acids, peptides and proteins

Hawkins, CL, Pattison, DI, Davies, MJ

Amino Acids 2003
Participants
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Output
Participant Of
hasEvent
Authored
Shamovsky, V  (2018-10-23)
Reviewed
Nüsse, O  (2018-11-07)
Created
Shamovsky, V  (2018-10-23)