S1P binds S1PR3 in response to E2 stimulation

Stable Identifier
R-HSA-9625813
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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S1P binds to its GPCR receptor S1PR3 downstream of E2 stimulation and GPER1 (Sukocheva et al, 2003; Sukocheva et al, 2006). S1P-bound S1PR3 promotes transactivation of the EGFR signaling pathway through the MMP-dependent liberation of HBEGF from the plasma membrane, leading to EGFR and MAPK phosphorylation (Sukocheva et al, 2003; Sukocheva et al, 2006; Kim et al, 2000; Tanimoto et al, 2004; Filardo et al, 2000; Razandi et al, 2003).

Literature References
PubMed ID Title Journal Year
12588983 Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane

Razandi, M, Alton, G, Pedram, A, Ghonshani, S, Webb, P, Levin, ER

Mol. Cell. Biol. 2003
11185956 Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells

Kim, JH, Kim, J H, Song, WK, Kim, J H, Chun, JS

IUBMB Life 2000
16636149 Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1

Sukocheva, O, Wadham, C, Holmes, A, Albanese, N, Verrier, E, Feng, F, Bernal, A, Derian, CK, Ullrich, A, Vadas, MA, Xia, P

J. Cell Biol. 2006
12881510 Sphingosine kinase transmits estrogen signaling in human breast cancer cells

Sukocheva, OA, Wang, L, Albanese, N, Pitson, SM, Vadas, MA, Xia, P

Mol. Endocrinol. 2003
11043579 Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

Filardo, EJ, Quinn, JA, Bland, KI, Frackelton, AR

Mol. Endocrinol. 2000
15044318 Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells

Tanimoto, T, Lungu, AO, Berk, BC

Circ. Res. 2004
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