MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4

Stable Identifier
R-HSA-9625520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Based on studies in mice, FOXO1 and the p-2S-SMAD2/3:SMAD4 complex directly stimulate transcription of the MSTN gene, encoding myostatin. Myostatin is a TGF-beta family member that restricts muscle growth by stimulating differentiation of myoblasts (Allen and Unterman 2007).
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