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MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4
Stable Identifier
R-HSA-9625520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4 (Homo sapiens)
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Based on studies in mice, FOXO1 and the p-2S-SMAD2/3:SMAD4 complex directly stimulate transcription of the MSTN gene, encoding myostatin. Myostatin is a TGF-beta family member that restricts muscle growth by stimulating differentiation of myoblasts (Allen and Unterman 2007).
Participants
Input
MSTN gene [nucleoplasm]
(Homo sapiens)
Output
MSTN homodimer [extracellular region]
(Homo sapiens)
Participates
as an event of
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
This event is regulated
Positively by
Regulator
FOXO1:p-2S-SMAD2/3:SMAD4:MSTN gene [nucleoplasm]
(Homo sapiens)
Active Unit
FOXO1 [nucleoplasm]
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
Inferred From
Mstn gene expression is stimulated by FOXO1 and p-2S-Smad2/3:Smad4 (Homo sapiens)
Authored
Orlic-Milacic, M (2018-10-23)
Reviewed
Donlon, T (2018-10-23)
Created
Orlic-Milacic, M (2018-10-20)
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