MSTN gene expression is stimulated by FOXO1 and p-2S-SMAD2/3:SMAD4

Stable Identifier
R-HSA-9625520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies in mice, FOXO1 and the p-2S-SMAD2/3:SMAD4 complex directly stimulate transcription of the MSTN gene, encoding myostatin. Myostatin is a TGF-beta family member that restricts muscle growth by stimulating differentiation of myoblasts (Allen and Unterman 2007).

Participants
Participant Of
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!