FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter

Stable Identifier
R-HSA-9625510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter
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Based on studies in mice, FOXO1 and the p-2S-SMAD2/3:SMAD4 complex bind the promoter of the MSTN gene, encoding myostatin (Allen and Unterman 2007). FOXO3 and glucocorticoid receptor (NR3C1, also known as GR) were reported to bind MSTN promoter in porcine cells (Jia et al. 2016).

Participants
Input
Output
Participant Of
hasEvent
Inferred From
FOXO1 and p-2S-Smad2/3:Smad4 bind Mstn gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-20)