STK11 gene transcription is stimulated by FOXO3,FOXO4

Stable Identifier
R-HSA-9625378
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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STK11 gene transcription is stimulated by FOXO3,FOXO4
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Transcription of the STK11 (LKB1) gene, encoding Serine/threonine-protein kinase STK11 (also known as Liver kinase B1) is directly stimulated by FOXO3 and FOXO4. It is unclear if FOXO3 and FOXO4 cooperate with NF-Y and SP1, which can also bind to the STK11 gene promoter, in the induction of STK11 transcription (Lutzner et al. 2012). STK11 regulates diverse cellular processes, including apoptosis (reviewed in Zhao and Xu 2014).
Literature References
PubMed ID Title Journal Year
22412893 Gene expression of the tumour suppressor LKB1 is mediated by Sp1, NF-Y and FOXO transcription factors

Lützner, N, Rösl, F, De-Castro Arce, J

PLoS ONE 2012
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
FOXO3,FOXO4:STK11 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3,FOXO4 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
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