GCK gene expression is inhibited by FOXO1, SIN3A and HDACs

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R-HSA-9625124
Type
Reaction [omitted]
Species
Homo sapiens
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Based on studies in mice, FOXO1, together with SIN3A and histone deacetylases (HDACs), directly represses transcription of the GCK gene, encoding glucokinase. Insulin interferes with FOXO1-mediated repression of GCK expression, resulting in upregulation of GCK and stimulation of lipogenesis (Langlet et al. 2017).

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