miR-33B:AGO2 [cytosol]

Stable Identifier
R-HSA-9624930
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
miR-33B:EIF2C2, miR-33B Endonucleolytic Minimal RISC, Argonaute2:miR-33B (single-stranded)
Locations in the PathwayBrowser
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
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